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Each CAM therapy was analyzed in separate unadjusted and adjusted Poisson regression models with a robust error variance that estimated the relative risk of CAM use, comparing participants with 1 and 2 or more chronic conditions with participants with no chronic conditions (the reference group).
Bonferroni procedures (24) were used to account for multiple comparisons; the standard α level of 5% was divided by 17 (the total number of specific CAM therapies plus the CAM index) to create a corrected α level of .003.
Understanding use of specific CAM modalities among people with multiple chronic conditions could increase knowledge about CAM therapies and disease management.
The 2012 National Health Interview Survey (NHIS) (20) is a cross-sectional household survey conducted annually by the Centers for Disease Control and Prevention of the US noninstitutionalized, civilian population.
More than 50% of the US population uses dietary supplements including multivitamins or minerals and singular vitamin and mineral supplements, and this use has increased over the past 20 years (22).
Because use is so widespread and the risk for supplements to interact with standard pharmaceutical treatments is high (23), it is important to describe all supplement use.
Therefore, we analyzed these individual therapies and 3 CAM indices; all CAM, excluding multivitamins or minerals, and further excluding singular vitamin and mineral supplements.
The 2012 NHIS data set included 34,525 adults (people aged 18 or older).
People were excluded from this analysis if they had missing data on all CAM variables (n = 968), leaving a final sample size of 33,557.